Indexing PCR for our scRNA-seq performed 03/17/25
Completion of the scRNA-seq experiment carried out on 03/17/25, with indexing PCR to identify samples in data analysis after sequencing.
OUR BOSS
Use the Force? No! She uses coffee and dominates the miRlab! Sandra Marcia Muxel is the name of her
Sandra Márcia Muxel
Our Master Yoda
Educating Mini-Jedis since 2012
micro RNAs
Small RNAs that can control gene expression
MicroRNAs are small RNA molecules that regulate gene expression, playing crucial roles in various biological processes and diseases, including leishmaniasis.
long non-coding RNAs
Regulate gene expression without coding for proteins
LncRNAs are transcripts longer than 200 nucleotides that do not encode proteins but play key roles in gene regulation, chromatin remodeling, and cellular processes, impacting development and disease.
Vaccine Strategies
Innovative approaches for immune protection
Vaccine strategies aim to stimulate immunity, providing protection against infectious diseases through various techniques like mRNA and vector-based vaccines.
Recent Activities
Celebrating our PhD student Ian's birthday!
Cheers to Ian on his birthday! Wishing our PhD student a year full of success, laughter, and new achievements!
scRNA-seq day studying Leishmania infection
Analyzing lymphocyte activation and evaluating how TLR2 interferes with T lymphocyte activation in leishmania infection using scRNAseq.
Lab Meeting
miR-9 and DCs differentiation
MicroRNA-9 Fine-Tunes Dendritic Cell Function by Suppressing Negative Regulators in a Cell-TypeSpecific Manner
We recently read and discussed this paper in our last Lab Meeting. Below, you’ll find a brief overview and a link to the full text!
"Dendritic cells (DCs) are innate immune cells that rapidly activate upon stimulation. They show that miR-9 is upregulated in bone marrow-derived DCs and conventional DC1s—but not DC2s—enhancing activation, T cell stimulation, and tumor control. miR-9 regulates transcriptional repressors like Pcgf6, driving DC maturation by modulating negative regulators in a cell-type-specific manner."